At 27, Arata Kaizaki is unemployed and struggling to find his place in life. His fortunes change when he meets Ryou Yoake from the ReLIFE Organization, who offers him a chance to become 17 again through an experimental pill. Transformed into a high school student, Kaizaki must complete one year of school as a research subject. As he navigates teenage life with an adult mind, he discovers new friendships and opportunities for personal growth, all while knowing his classmates' memories of him will be erased once the experiment ends.