When high school students mourn the brutal murder of their classmate Tomie Kawakami, she mysteriously appears at the classroom door, alive and unchanged. This begins a series of supernatural events centered around Tomie, a beautiful woman with a distinctive beauty mark under her left eye. She possesses the power to enchant men, driving them to obsessive love that inevitably turns violent. Despite being repeatedly murdered and dismembered, Tomie always regenerates, continuing her eternal cycle of seduction, manipulation, and death.